Fermentation /Protein Expression Engineer

Location: LEBANON, NH

Type: Full Time

Min. Experience: Experienced

About Avitide

Avitide is a biotechnology company that provides a platform technology to rapidly discover, develop and supply high-performance affinity purification solutions for the biopharmaceutical manufacturing industry.  Avitide is seeking a qualified candidate to join a motivated and interdisciplinary team of scientists and engineers to help realize this exciting opportunity. The Avitide technology enables its partners with exclusive, high-yield, high purity affinity separation technologies that are delivered with an industry-leading service timeline to reduce cost of manufacturing and accelerate the delivery of new medicines to patients. 

Avitide's founding team brings substantial expertise and a track record of success in commercializing innovative biopharmaceutical discovery and manufacturing platform technologies.  Avitide is financed by top-tier venture capital firms such as Polaris Venture Partners, OrbiMed Advisors, SV Life Sciences, NeoMed Management, Mithril Capital Management, Sands Capital Ventures and Borealis Ventures.

Avitide is housed in a modern 30 000 square foot facility that is located in New Hampshire’s beautiful Upper Connecticut River Valley, and is minutes from Dartmouth College, the Geisel School of Medicine, the Thayer School of Engineering, the Tuck School of Business, and Dartmouth-Hitchcock Medical Center.  The surrounding New Hampshire and Vermont areas are renowned for its premier skiing, hiking, kayaking, and biking.  Avitide offers compensation packages comprised of competitive salary, bonus, benefits and equity components, and career growth solely based upon merit.

 

About This Position

The Fermentation Engineer will lead an expanded initiative to produce recombinant ligands that are defining components of Avitide developed affinity resins intended for clinical manufacturing programs. This work will span strain screening/optimization, process development and lab scale fermentation culminating in liaising with contract manufacturing organizations for efficient technical transfer. It requires a creative individual who can work hands-on as part of a dynamic and integrated team. The candidate will also be the primary technical expert for fermentation and process development, providing technical leadership, troubleshooting support and guidance for benchtop fermentation screening through process transfer.  Avitide seeks candidates who are highly self-motivated and can work in a collaborative fashion with other interdisciplinary team members in a fast-paced and exciting work environment.

Qualifications and Experience:

  • Extensive experience with laboratory scale microbial fermentation for recombinant protein production in hosts such as E. Coli, Saccharomyces, Pichia and Bacillus
  • Strong knowledge of basic protein biochemistry, microbiology, and recombinant protein expression in microbial hosts
  • Experimental design and data analysis capabilities including Design of Experiments (DOE)
  • Command of modern computer controlled fermentation systems
  • Experience with downstream processing unit operations such as centrifugation, homogenization, ultrafiltration is desirable
  • Must be self-motivated and able to work under tight deadlines
  • Excellent interpersonal and communication (oral and written) skills, documentation, organization, good record keeping, writing reports and SOPs
  • Able to work effectively in cross functional teams to solve manufacturing problems or implement improved procedures
  • Experience with management of and technical transfer to CMOs. Direct experience with larger scale fermentation (>100 L and > 1000 L) is welcome
  • Degree (BS/MS/PhD) in sciences or engineering
  • 3+ years of experience in a laboratory setting
  • Demonstrated history of strong hands-on ability, problem solving, and independent experimental design and execution

 Duties and Responsibilities:

  • Design and execution of fermentation screening and benchtop fermentation and recovery processes for recombinant proteins expressed in microbial hosts
  • Optimization of fermentation processes using scale down models to predict performance at manufacturing scale
  • Identifying and evaluating new technologies to improve fermentation and recovery processes
  • Participation in strain and ligand optimization efforts as part of an integrated effort to produce optimized ligands for resin development and manufacturing
  • Independently designing and executing experiments and communicating results and challenges to stakeholders
  • Writing process SOPs and supporting strain and process transfer

Avitide Cultural Qualities

  • Demonstrate creativity and innovation
  • Actively contribute to our collaborative team culture
  • Ability to work autonomously and effectively under broad directives
  • Agile and quick to adapt
  • Excellent and timely communication skills
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